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M94A1839.TXT
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1994-10-24
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Document 1839
DOCN M94A1839
TI Between gender comparative dynamics of biological markers of HIV disease
progression.
DT 9412
AU de Vincenzi I; Jadand C; Deveau C; Bucquet D; European Centre for the
Epidemiological Monitoring of AIDS,; Saint-Maurice, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):44 (abstract no. 151C). Unique
Identifier : AIDSLINE ICA10/94370736
AB OBJECTIVE: To compare the dynamics of biological markers of disease
progression in HIV infected males and females. METHODS: Since 1988,
non-haemophiliac asymptomatic patients for whom the 1st HIV+ test was
not older than 12 months and patients for whom the date of infection was
known were enrolled in the French cohort SEROCO and followed-up. Mean
lymphocyte (absolute T4 counts, %T4, T4/T8) and type A Immunoglobulin
(IgA) levels were compared between males and females at 12, 24, 36, 48
and 60 months after infection for subjects with a date of infection that
could be estimated at +/- 1 year (Student t test). RESULTS: Significant
differences between males (M) and females (F) were found up to 60 months
after infection. These differences are not explained by age at
infection, route of infection, centre of enrolment, and time between
infection and inclusion in the cohort. A comparison of the prognostic
value of these markers will be presented. TABULAR DATA, SEE ABSTRACT
VOLUME. CONCLUSION: These results are in favour of less severe
immunological disorders in women compared to men in the first years of
infection. It is also possible that immunological markers do not have
the same prognostic value in men and women. Such differences should be
clarified for the use of these markers in clinical trials including men
and women.
DE Biological Markers/BLOOD Cohort Studies Comparative Study CD4-CD8
Ratio Female Follow-Up Studies France/EPIDEMIOLOGY Human HIV
Infections/*BLOOD/EPIDEMIOLOGY/*IMMUNOLOGY IgA/BLOOD Leukocyte Count
Male Prognosis Sex Characteristics Time Factors T4 Lymphocytes
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).